Dr. Sheth's Ceramide & Vitamin C Sunscreen - Clinical Testing
Dr. Sheth's Ceramide & Vitamin C Sunscreen SPF 50+ PA++++
Independently tested at CCFT Laboratories - In-Vivo SPF 52.66, CTRI/2025/03/083105, Formulated honoring the legacy of Dr. Rekha Sheth, Pioneer of Cosmetic Dermatology in India.
At a Glance
| In-Vivo SPF | In-Vitro SPF | PA Rating | Broad Spectrum | Boots Star | Blue Light Protection |
|---|---|---|---|---|---|
| 52.66 | 63.48 | PA++++ | Yes | *** | Yes |
This product has been evaluated for sunscreen efficacy at CCFT Laboratories Pvt. Ltd. in accordance with international standards. Results are documented in full below.
1. Study Overview & Design
| Study Parameter | Detail |
|---|---|
| Study Title | Sunscreen Efficacy Study — Dr. Sheth's Ceramide & Vitamin C Sunscreen SPF 50+ PA++++ |
| Specific Parameters Measured | Sun Protection Factor (SPF) - In-vivo & In-vitro, UVA Protection (PA Rating), Broad Spectrum Classification, Boots Star Rating, Blue Light Protection |
| Why These Parameters Matter | UVB radiation causes sunburn and contributes to skin cancer; UVA radiation penetrates deeper, causing photoaging, tanning, and long-term structural skin damage. Comprehensive sun protection requires verified defense across both wavelength ranges. The PA rating system communicates UVA protection levels, while Boots Star Rating confirms the balance of UVA to UVB protection. Blue light protection addresses emerging concerns about high-energy visible light-induced skin damage. |
| Study Type | In-vivo and in-vitro sunscreen efficacy evaluation |
| Testing Methods | ISO 24444:2019 (In-vivo SPF), COLIPA Guideline (In-vitro SPF, UVA-PF, Broad Spectrum, Boots Star) |
| Specific Product Studied | Dr. Sheth's Ceramide & Vitamin C Sunscreen SPF 50+ PA++++ (exact commercial formulation) |
| Product Connection | The formulation combines six UV filters with Ethyl Ascorbic Acid (Vitamin C), five Ceramide types, Niacinamide, Hyaluronic Acid, and Kakadu Plum Extract to deliver very high broad-spectrum protection (SPF 52.66, PA++++) while providing antioxidant defense, barrier support, and blue light protection. |
2. Claim Substantiation Matrix
| Claim | Certificate | Evidence | Status |
|---|---|---|---|
| SPF 50+ | Sunscreen Efficacy Certificate | In-vivo SPF 52.66 - ISO 24444:2019 | Supported |
| PA++++ | Sunscreen Efficacy Certificate | PA++++ rating - COLIPA Guideline | Supported |
| In-Vivo Tested | Sunscreen Efficacy Certificate | ISO 24444:2019 in-vivo study on human participants | Supported |
| Broad Spectrum | Sunscreen Efficacy Certificate | Confirmed broad spectrum protection | Supported |
| Boots Star *** | Sunscreen Efficacy Certificate | 3-star rating - good UVA/UVB balance | Supported |
| Blue Light Protection | Sunscreen Efficacy Certificate | Confirmed blue light defense | Supported |
| CTRI Registered | Clinical Trials Registry | CTRI/2025/03/083105 - registered 21/03/2025 | Verified |
3. Sunscreen Efficacy Study Details
Category: Efficacy | Testing Laboratory: CCFT Laboratories, March 2025
3.1 Lab, Date, Standards and Registration
| Field | Detail |
|---|---|
| Product Tested | Dr. Sheth's Ceramide & Vitamin C Sunscreen SPF 50+ PA++++ |
| Sponsor / Brand Owner | Dr. Sheth's |
| Testing Laboratory | CCFT Laboratories Pvt. Ltd., Meerut |
| Lab Certifications | ISO 9001:2015, ISO 45001:2015, OECD GLP Compliant |
| Lab Classification | FIST Centre - Dept. of Science & Technology, Govt. of India |
| CTRI Registration No. | CTRI/2025/03/083105 |
| Registration Date | 21 March 2025 |
| In-Vivo Test Method | ISO 24444:2019 |
| In-Vivo SPF Result | 52.66 |
| In-Vitro Test Method | COLIPA Guideline |
| In-Vitro SPF Result | 63.48 |
| PA Rating | PA++++ |
| Broad Spectrum | Yes |
| Boots Star Rating | *** |
| Blue Light Protection | Yes |
| Signed By | Puneet Mittal, Director R&D & Nidhi Dixit, Clinical Research Associate, CCFT Laboratories Pvt. Ltd. |
3.2 Test Results
| Outcome | Result | Clinical Classification |
|---|---|---|
| SPF (In-Vivo) | 52.66 | Very high protection - top tier of SPF scale |
| SPF (In-Vitro) | 63.48 | Confirms formulation consistency; exceeds in-vivo result |
| PA Rating | PA++++ | Highest achievable tier - requires UVA-PF of 16 or above |
| Broad Spectrum | Yes | Protection verified across both UVB and UVA wavelengths |
| Boots Star Rating | *** | Good UVA protection - UVA to UVB protection ratio of 60-80% |
| Blue Light Protection | Yes | Confirmed defense against high-energy visible light |
3.3 Clinical Interpretation of Results
| Metric | Interpretation |
|---|---|
| SPF 52.66 (In-Vivo) | Under standardized lab conditions per ISO 24444:2019, the product demonstrated approximately 53 times more protection against UVB-induced skin damage compared to unprotected skin. This result classifies the product as SPF 50+, the highest tier on the international SPF scale, indicating very high UVB protection. |
| SPF 63.48 (In-Vitro) | The in-vitro result of 63.48, measured using the COLIPA guideline optical method, exceeds the in-vivo result of 52.66. This is an excellent signal of formulation robustness - the product demonstrates strong UV filter performance in controlled laboratory conditions, with real-world (in-vivo) performance confirming reliable protection. |
| PA++++ | PA++++ is the highest category in the PA (Protection Grade of UVA) rating system used across India, Japan, South Korea, and Southeast Asia. It requires a UVA-PF of 16 or above, signifying very high defense against UVA rays responsible for tanning, photoaging, and deep skin damage. |
| Boots Star Rating *** | The Boots Star Rating measures the ratio of UVA protection to UVB protection. Three stars indicates a good UVA-to-UVB ratio (60-80%), meaning the formula provides balanced protection and does not over-index on UVB at the expense of UVA. Combined with PA++++, this confirms both high absolute UVA protection and well-balanced spectral coverage. |
| Broad Spectrum: Yes | Broad spectrum certification means the product's UV protection does not concentrate only in the UVB range but extends meaningfully across UVA wavelengths as well. This matters because UVB and UVA cause different types of skin damage - a sunscreen that covers both is significantly more protective than one that addresses only one range. |
| Blue Light Protection: Yes | Blue light (high-energy visible light, 400-500 nm) can induce oxidative stress, hyperpigmentation, and premature aging. The confirmed blue light protection indicates the formulation contains ingredients that help defend against this emerging environmental stressor, particularly relevant for daily urban exposure. |
3.4 Formulation Architecture & UV Filter System
Dr. Sheth's Ceramide & Vitamin C Sunscreen was tested exactly as commercially available. The formulation uses a comprehensive multi-filter system designed for broad-spectrum coverage, photostability, and skin quality benefits, honoring Dr. Rekha Sheth's legacy of evidence-based dermatological formulations.
| Formulation System | Key Components | Function & Performance Rationale |
|---|---|---|
| UVB Filter System | Ethylhexyl Methoxycinnamate (Octinoxate), Phenylbenzimidazole Sulfonic Acid (Ensulizole), Ethylhexyl Salicylate (Octisalate) | Three UVB-focused filters work synergistically to provide strong absorption across the 290-320 nm range, contributing to the SPF 52.66 result. Ethylhexyl Salicylate also functions as an Avobenzone photostabilizer. |
| UVA Filter System | Butyl Methoxydibenzoylmethane (Avobenzone), Terephthalylidene Dicamphor Sulfonic Acid (Mexoryl SX) | Avobenzone provides excellent absorption at the 360 nm range; Mexoryl SX complements with broader UVA coverage. Together, they are the primary drivers of the PA++++ rating and broad spectrum classification. |
| Broad Spectrum Anchor | Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) | A dual-mechanism filter that both absorbs and scatters UV radiation across both UVA and UVB ranges. Tinosorb M is one of the most photostable UV filters available and plays a critical role in anchoring the overall protective range and achieving balanced broad spectrum coverage. |
| Photostabilization System | Ethylhexyl Salicylate, Tinosorb M | Avobenzone is inherently photounstable when used alone. This formula contains two established Avobenzone photostabilizers: Ethylhexyl Salicylate and Tinosorb M. Their inclusion ensures the UV filters maintain their protective performance under UV exposure, supporting the durability of the measured protection. |
| Vitamin C System | Ethyl Ascorbic Acid (Vitamin C), Terminalia Ferdinandiana (Kakadu Plum) Fruit Extract | Ethyl Ascorbic Acid is a stable, oil-soluble form of Vitamin C. Kakadu Plum has the highest natural Vitamin C content of any fruit. Together, they provide potent antioxidant activity, support skin brightening, and contribute to blue light protection by neutralizing free radicals generated by high-energy visible light. |
| Ceramide Barrier Complex | Ceramide EOP, NG, NP, AS, AP; Cetyl-PG Hydroxyethyl Palmitamide, Cholesterol | Five ceramide types working together alongside a pseudo-ceramide and cholesterol constitute a comprehensive skin-identical barrier repair system. Ceramides make up approximately 50% of the skin barrier's lipid matrix. This complex supports barrier integrity, prevents transepidermal water loss, and is particularly relevant for maintaining skin health under daily sun exposure. |
| Hydration System | Hyaluronic Acid, Glycerin, Propylene Glycol, Aquaxyl Complex | Multi-level hydration architecture. Hyaluronic Acid is the primary humectant. Aquaxyl is a patented complex designed to address moisture at multiple skin depths. This system supports comfortable, non-drying wear - particularly relevant for daily-use sunscreen. |
| Skin Tone Actives | Niacinamide, Glycyrrhiza Glabra (Licorice) Root Extract | Niacinamide (Vitamin B3) supports the skin barrier and is widely studied for its role in supporting even skin tone. Licorice root contains glabridin, a compound with documented skin-brightening properties. Together, they help address hyperpigmentation and support uniform skin tone. |
| Soothing Botanical System | Aloe Barbadensis (Aloe Vera) Extract, Chamomilla Recutita (Chamomile) Flower Extract, Allantoin, Capsicum Annuum Fruit Extract | Aloe and Chamomile provide documented anti-inflammatory and soothing properties. Allantoin supports skin conditioning and comfort. These ingredients help maintain skin comfort during daily sun exposure and support the formulation's tolerability profile. |
| Texture & Distribution System | Dimethicone, Cyclopentasiloxane, Isododecane, Tapioca Starch, Sodium Polyacrylate, Xanthan Gum, Olivem 1000 | The gel-cream matrix ensures uniform UV filter distribution across skin. Dimethicone and Cyclopentasiloxane create a smooth, comfortable feel. Isododecane aids rapid, even spreading before evaporating. Tapioca Starch absorbs excess sebum and provides a comfortable finish. Even distribution is critical - gaps in application create gaps in protection regardless of filter quality. |
| Antioxidant System | Tocopheryl Acetate (Vitamin E), Laminaria Digitata Extract, Biosaccharide Gum-4 | Vitamin E works synergistically with Vitamin C to provide enhanced antioxidant protection. Marine algae (Laminaria) contributes additional antioxidant activity. This system supports protection against UV-induced oxidative stress and contributes to blue light defense. |
3.5 Exclusion Profile: What is Not in This Formula
| What is absent | Why it matters |
|---|---|
| No mineral oil | Formula uses lightweight emollients (Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Neopentyl Glycol Diheptanoate) rather than petrolatum derivatives, supporting comfortable daily wear. |
| No heavy occlusives | The formulation avoids heavy waxes and butters that can create greasy feel, supporting comfortable daily wear under makeup or alone. |
| No parabens | Avoids methylparaben, propylparaben, and related compounds that have documented sensitization potential in some populations. |
4. Published Research on Key Actives
4.1 Ingredient Efficacy & Relevance
| Ingredient | Primary Published Finding | Relevance to Product |
|---|---|---|
| Ethyl Ascorbic Acid (Vitamin C) | Stable Vitamin C derivative for skin brightening and antioxidant protection. Ethyl Ascorbic Acid is among the most chemically stable Vitamin C derivatives. Published research demonstrates that stable Vitamin C derivatives significantly improve skin brightness, reduce hyperpigmentation, and provide antioxidant protection against UV-induced oxidative stress. | Provides antioxidant support for daily sun exposure, contributes to skin brightening, and supports blue light protection by neutralizing free radicals. |
| Kakadu Plum (Terminalia Ferdinandiana) | Highest natural Vitamin C content. Kakadu Plum contains up to 100 times more Vitamin C than oranges by weight. Research documents its potent antioxidant capacity and ability to neutralize free radicals generated by environmental stressors including UV and blue light. | Enhances the Vitamin C system with natural antioxidant activity, contributing to blue light protection and overall oxidative stress defense. |
| Ceramides (EOP, NG, NP, AS, AP) | Skin barrier support and TEWL reduction. A comprehensive review in the American Journal of Clinical Dermatology established that ceramides account for approximately 50% of the lipid matrix of the human stratum corneum and are essential for TEWL regulation. | Supports barrier integrity under daily sun exposure, prevents moisture loss, and maintains skin health - particularly relevant for long-term sunscreen use. |
| Niacinamide (Vitamin B3) | Skin barrier support and hyperpigmentation reduction. A randomized, double-blind study in the British Journal of Dermatology (2002) found that topical application of 5% niacinamide significantly reduced hyperpigmented spot area compared to vehicle control after 8 weeks. | Supports even skin tone, reduces hyperpigmentation risk from sun exposure, and strengthens barrier function. |
| Tinosorb M | Broad-spectrum coverage and photostability. Research demonstrates Tinosorb M is one of the most photostable UV filters available and functions as an Avobenzone photostabilizer through energy transfer mechanisms. | Critical for achieving broad spectrum classification, balanced Boots Star rating, and maintaining protection under UV exposure. |
| Licorice Root Extract (Glycyrrhiza Glabra) | Skin brightening and anti-inflammatory activity. Licorice root contains glabridin, which has been shown to inhibit tyrosinase activity and reduce hyperpigmentation. Published studies document its anti-inflammatory properties and ability to support even skin tone. | Contributes to skin brightening and helps address sun-induced hyperpigmentation. |
4.2 Published Evidence Summary
| Ingredient | Primary Published Finding | Study Type | Evidence Level | Claim Supported |
|---|---|---|---|---|
| Ethyl Ascorbic Acid | Improves skin brightness, reduces hyperpigmentation, antioxidant | In-vivo clinical | Strong | Antioxidant, brightening |
| Kakadu Plum | Potent antioxidant, high Vitamin C content | In-vitro + traditional use | Moderate | Antioxidant, blue light protection |
| Ceramides | Reduce TEWL, support barrier integrity | In-vivo clinical | Strong | Barrier support |
| Niacinamide | Reduces hyperpigmentation, improves barrier | In-vivo clinical | Strong | Even skin tone, barrier support |
| Tinosorb M | Broad-spectrum UV absorption, photostable, Avobenzone stabilizer | In-vitro + in-vivo | Strong | Broad spectrum, photostability |
| Licorice Root | Inhibits tyrosinase, reduces hyperpigmentation | In-vitro + in-vivo | Moderate | Brightening, even tone |
5. Common Questions About Sunscreen Efficacy and This Product
A: Under standardized laboratory conditions per ISO 24444:2019, SPF 52.66 means the product provides approximately 53 times more protection against UVB-induced skin damage compared to unprotected skin. It is classified as SPF 50+, the highest tier on the international SPF scale, indicating very high UVB protection.
A: PA++++ is the highest category in the PA (Protection Grade of UVA) rating system used across India, Japan, South Korea, and Southeast Asia. It indicates a UVA Protection Factor of 16 or above - signifying very high defense against UVA rays responsible for tanning, photoaging, and deep skin damage.
A: The Boots Star Rating measures the ratio of UVA protection to UVB protection. Three stars indicates a good UVA-to-UVB ratio (60-80%), meaning the formula provides balanced protection across both UV ranges. This is important because UVB and UVA cause different types of skin damage.
A: Blue light (high-energy visible light, 400-500 nm) is emitted by the sun, digital screens, and LED lighting. Research shows it can induce oxidative stress, hyperpigmentation (particularly in deeper skin tones), and premature aging. This product's confirmed blue light protection indicates it contains antioxidants (Vitamin C, Vitamin E, Kakadu Plum) that help neutralize free radicals generated by blue light exposure.
A: CTRI is the Clinical Trials Registry - India, a government-maintained public database administered under the Indian Council of Medical Research. Registering a study with CTRI creates a publicly verifiable record. The registration number CTRI/2025/03/083105 can be independently looked up at ctri.nic.in. Registration date was 21 March 2025.
A: CCFT Laboratories Pvt. Ltd. is a FIST Centre - a designation awarded by the Department of Science & Technology, Government of India. The lab holds ISO 9001:2015 and ISO 45001:2015 certifications and operates under OECD Good Laboratory Practice (GLP) guidelines. It is based at Meerut Institute of Engineering & Technology.
A: In-vitro testing measures UV filter performance in a controlled optical setup without human variables. In-vivo testing on human skin accounts for real-world factors like skin texture, application variation, and individual skin characteristics. The in-vivo result of 52.66 is the clinically relevant number - it confirms the product delivers SPF 50+ protection under actual use conditions. The higher in-vitro result indicates the formulation has strong UV filter capacity.
A: Dr. Rekha Sheth was India's first cosmetic dermatologist and a pioneer of evidence-based dermatological formulations. This product reflects her commitment to combining clinical efficacy with skin health: comprehensive UV protection (SPF 52.66, PA++++), barrier-supporting ceramides, proven actives (Vitamin C, Niacinamide), and antioxidant defense. The formulation prioritizes both sun protection and long-term skin quality - principles central to Dr. Sheth's dermatological philosophy.
A: The formulation includes soothing ingredients (Aloe Vera, Chamomile, Allantoin) and avoids common irritants like parabens and mineral oil. However, individuals with sensitive skin should patch test before full application and consult a dermatologist if they have specific concerns or diagnosed skin conditions.
A: This is a chemical sunscreen using organic UV filters (Avobenzone, Mexoryl SX, Tinosorb M, Octinoxate, Ensulizole, Octisalate), which typically provide more elegant texture and easier application compared to zinc oxide or titanium dioxide-based physical sunscreens.
6. Lab References and Certificate Details
| Field | Detail |
|---|---|
| Testing Laboratory | CCFT Laboratories Pvt. Ltd., Meerut |
| Lab Certifications | ISO 9001:2015, ISO 45001:2015, OECD GLP Compliant |
| Lab Classification | FIST Centre - Dept. of Science & Technology, Govt. of India |
| CTRI Registration No. | CTRI/2025/03/083105 |
| Registration Date | 21 March 2025 |
| In-Vivo Test Method | ISO 24444:2019 |
| In-Vitro Test Method | COLIPA Guideline |
| Sponsor / Brand Owner | Dr. Sheth's |
| Signed By | Puneet Mittal (Director R&D) & Nidhi Dixit (Clinical Research Associate), CCFT Laboratories Pvt. Ltd. |
| Certificate Date | March 2025 |
All certificates on this page reflect testing on the product formulation as commercially available. Results are test-specific. Real-world outcomes may differ from study conditions. Reapplication as directed on product packaging is recommended.
7. References
- Coderch L, et al. Ceramides and skin function. Am J Clin Dermatol. 2003;4(2):107-29. PMID: 12553851.
- Chamlin SL, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis. J Am Acad Dermatol. 2002;47(2):198-208. PMID: 12140467.
- Hakozaki T, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147(1):20-31. PMID: 12100180.
- Bissett DL, et al. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004;26(5):231-8. PMID: 18492135.
- ISO 24444:2019. Cosmetics - Sun protection test methods - In vivo determination of the sun protection factor (SPF). International Organization for Standardization; 2019.
- COLIPA. Method for the in vitro determination of UVA protection provided by sunscreen products. COLIPA; 2011.
- National Institutes of Health, Office of Dietary Supplements. Niacinamide Fact Sheet for Health Professionals. NIH; 2021.
- CCFT Laboratories Pvt. Ltd. Clinical Study Certificate for Dr. Sheth's Ceramide & Vitamin C Sunscreen SPF 50+ PA++++. CTRI/2025/03/083105. CCFT Laboratories; 2025.
- WebMD Medical Reference. Sunscreen: What to look for. WebMD; 2023.
- Healthline. Understanding SPF, PA ratings, and broad spectrum protection. Healthline Media; 2023.
Annexure: Formulation Legacy - Dr. Rekha Sheth
| Field | Detail |
|---|---|
| Name | Dr. Rekha Sheth (1950s - 2020) |
| Qualifications | MBBS, MD Dermatology |
| Professional Distinction | India's first cosmetic dermatologist; Pioneer of aesthetic dermatology in India |
| Career Achievement | Founded India's first dedicated aesthetic/cosmetic dermatology clinic in Mumbai (1993-1994) |
| Leadership Roles | Founder & President of Cosmetic Dermatology Society of India (1997); First Indian woman Vice President of International Society of Dermatology (2011) |
| International Recognition | Maria Duran Lectureship Award from International Society of Dermatology (2012); Invited speaker at American Academy of Dermatology and European Academy of Dermatology and Venereology |
| Industry Contribution | Consultant and clinical investigator for Hindustan Unilever and L'Oréal; Conducted cosmetic clinical studies under international Good Clinical Practice standards |
| Publications | Author of "The Beauty Book" focused on beauty and skincare for Indian skin |
| Legacy | Among the first physicians to introduce Botox, dermal fillers, and laser hair reduction into mainstream Indian dermatology practice. Recognized internationally for expertise on Indian skin and cosmetic dermatology. |
| Formulation Philosophy | Evidence-based dermatological formulations combining clinical efficacy with skin health; Emphasis on barrier support, antioxidant protection, and long-term skin quality alongside sun protection. |
